PARTIAL SEQUENCE AND PHYLOGENETIC ANALYSIS OF  HEV ISOLATED FROM VIETNAM

 

Nguyen Tuyet Nga, Nguyen Thu Van, Hoang Thuy Nguyen 1

Jihong Meng2,3, Michael A. Purdy, Yury E. Khudyakov, Howard A. Fields 3

1 National Institute of Hygiene and Epidemiology, Hanoi, Vietnam

2 Department of Microbiology and Immunology, Nanjing Railway Medical College,Nanjing, China

3 Hepatitis Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Center for Disease Control and Prevention, Atlanta,GA,USA

 

The nucleotide sequence from position 5966 to 6582 of the hepatitis E virus (HEV) genome was determined from a Vietnamese isolate obtained from the acute-phase sera of a sporadic case of acute hepatitis. This sequence was compared with the corresponding sequences of 17 HEV strains deposited in GenBank. This analysis revealed that the Vietnamese strain of HEV belongs to genotype 1 closely related to the Burma, India and Nepal subtypes. Phylogenetic analysis demonstrated genotype–specific nucleotides and amino acids within this region.