Nguyen Kim
Dung, Nguyen Thi Ngoc Nhi, Tran Thanh Son, Mai Nguyet Thu Hong,
Thieu Thi Tu, Nguyen Thi Huynh Lan, Nguyen Thi Anh Dao, Truong Xuan Lien.
Pasteur Institute in
Vietnamese Requirements to evaluate the general safety for vaccines has not been unified and realistic. Rabies vaccines asked for 14 days of observation meanwhile DTP vaccine only needs 7 days. The margin of gainweight under the observation is not given. This retrospective consideration provides some data of mice and guinea-pig that were used to test the general safety of rabies vaccines and other biological products (BP) at QC lab from 1987-2000.
Mice with Rabies vaccine IC and IP injection gained 3-3.5g (23-24.5%) after 1 week and 5.5-6.3g (41-43%) after 2 weeks observation.
Guinea-pig quarantine and guinea-pig injected with NaCl 0,9% gained 33–35g (11–13%) in 1W and 90g (24%) in 2Ws. Meantime, guinea-pig given Rabies vaccines and other BPs IP got 15–30g (5–9% weightgained) after 7 days and 40–60g (18–19%) after 14 days.
The rate of gaining weight of mice and guinea-pig at QC lab was lower than in some of other manufactures that were reported. So, the improvement in animal care system needs to be fulfill.