Le Thi Anh Hong
National Institute of Hygiene and Epidemiology, Hanoi
Summary
519 strains S.typhi clinical isolated from Northern, Southern and Center
regions of Vietnam
since 1995 to 2002. They were 142 S.typhi
strains MDR selected among 426
strains Multi-Drug-Resistant analyzed by typed and compared. Plasmid analysis,
bacteriophage typing and ribotyping showed that: all the S.typhi harbored a large plasmid 122 MDa and 50 of them contained a
second plasmid 63 MDa, they were auto transferable plasmid and the frequency of
transfer shifted from 10-8 to 10-5, the multiple drug
resistance is associated with a 122 MDa. Lysotype E1 and E3 were predominant
and ribotype 3a were observed for 96,3% of the strains
studied, it conclude that they were a single clonal.