Pasteur Intitute HCM city, Center for Preventive Medicine,
Center for Tropical Diseases, Binh Trieu centre,
National Association of AIDS
- Determination of the principal clinical and biological characteristics of the infection of HIV 1 in a target population.
- Evaluation of the feasibility of the cohort study with HIV seropositivity.
Clinical status: Except the patients of pulmonary tuberculosis who reside in the specific center, the frequent clinical status is:
|
|
HIV + |
HIV – |
|
Zona |
20% |
0% |
|
Candidiasis |
58% |
22% |
|
Adenopathia |
85% |
58% |
Biological status:
|
|
HIV + |
HIV – |
|
Anemia |
25 % |
7% |
|
Thrombocytopenia |
2% |
0% |
|
CD4 |
337/ ml |
719/ ml |
|
CD8 |
1114 / ml |
835 ml |
In 60% of the HIV seropositive group, the numbers of CD4 are within 200 – 499/ ml.
The seroprevalence of the infection non-HIV as HTLV, HCV, HBV, CMV, HSV and VZV are strictly elevated in both of the groups HIV+ and HIV–. In the meantime, the prevalence of toxoplasmose is very low (<10%) in the both groups.
According to the classification table of CDC, we have the proportion of the subjects with HIV seropositive as follows:
Stage A : 24 %
Stage B : 34 %
Stage C: 42%
In the first year, among 300 of drug abusers recruited (12/1996) for the study, 254 were HIV seropositive, 46 HIV seronegative. After one year (1/98) we found only 119 HIV seropositive and 22 HIV seronegative. Among the seropositive subjects, 24 were deceased.
To ensure the sample for the study, 127 new subjects (55 with HIV+ and 72 with HIV–) were recruited.
The study will be realized every 6 months on the clinical consultation and the blood biological parameters.