Nguyen Thi Kim Tien – Director of Pasteur Institute of
A descriptive prospective study of Dengue Fever (DF) and Dengue Haemorrhagic Fever (DHF) hospitalised was undertaken in An Giang General Hospital, An Giang Province from April 2002 to May 2003. A first blood sample (BS) will be perform on admission to detect dengue antibody by Elisa (IgM and IgG) and virus isolation. The second BS will be drawn on discharge with the same test. If the patient is discharged less than 10 days after the onset of fever, a third BS will be planned, for IgM and IgG. In the hospital, all patients will be follow-up adequate platelet count and haematocrit.
- There is 1009 patient selected (less than 15 years old), 5 DHF deaths due to DHF and 4 deaths due to others. Classification of the Dengue hospitalized cases: DF (28, 5%), DHF (49%) and DSS (10%).
- The highest positive IgM rate is belong to DSS patient group (89%) in the 2nd BS, then DHF (67%), DF (34%), viral infection. Similarly, the virus isolated rate of the DSS patient group is highest (15%), and DHF (14, 6%). DEN2 is predominant (with 84% of all virus isolated), and then DEN4 (8, 8%).
- On the admission, pediatrician had tendency to overload Dengue diagnosis. There is 11, 6% cases with DF/DHF on the admission but they are typhoid fever, measles and viral infection on the discharge.
- Only 22,8% DHF cases, 69,4% DSS cases correspond to two laboratory findings criteria for Dengue (platelet count under 100.000/mm3 and a rise in the haematocrit equal to or greater than 20% above average). On the contrary, there is 67, 5 % DHF cases, 68,8% DSS cases with platelet count above 100.000/mm3 or a rise in the haematocrit equal to or less than 20%.
- The laboratory findings is the more severe (platelet count under 100.000/mm3 and a rise in the haematocrit equal to or greater than 20% above average), the more positive IgM rate (above 90%) and virus isolated.